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This extended half-life has given Cialis a much longer duration of action. Cialis is licensed to work up to 36 hours while Viagra is thought to work for a maximum of around 8 hours. Since the successful release of Viagra to the market there have been other successful ED drugs synthesized to work on the same PDE5 enzyme. The preference a patient may have for one of these drugs over another is often down to them trying the different ED medications and choosing the one that gives them optimal effect with the least side-effects. With millions of dollars already invested in the project it was a brave step to change the direction of the drug development. The research had understandably already attracted some publicity in light of these unexpected results and many ED sufferers had began writting to the research team outlining how important the medication would be for their well-being. Scientists in Sandwich, UK, had been working to create a medication that would work on blocking the PDE5 enzyme to help treat cardiovascular issues such as Angina by way of vasodilating the arteries around the heart.

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In the early months of stage one in the clinical trials however, some peculiar effects that had not been anticipated were being observed. At the time, Ian Osterloh, the lead clinical researcher, noted that several men were getting erections days after the initial dose of the drug. His initial thought was even if it was true effect ‘who would want to take a drug on a Wednesday to get an erection on Saturday? Around the same time as these results were being reported a separate study was published uncovering the biochemical pathway of erections.

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There has been a lot of talk of studies showing different food sources helping ED. In reality, you should examine your own diet and what it may be lacking. Cialis was approved by the FDA in 2003, marketed originally as an ED drug, it’s licensed was later adapted to be indicated for treatment of pulmonary hypertension and benign prostatic hyperplasia .